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Xymogen SynovX T & L 60 Veggie Caps

Brand: Xymogen

SynovX T & L

  • Made In Canada
  • Helps to relieve joint pain associated with osteoarthritis

It is known that tendons and ligaments have a slower and more limited ability to self-repair than other tissues. However, healthy tendons and ligaments do indeed have an intrinsic capacity for repair, which is controlled by resident fibroblasts and their surrounding extracellular matrix (ECM). Fibroblasts (e.g., tenocytes) are responsible for producing the ECM and therefore the proteoglycans (protein/mucopolysaccharide complex) and collagen needed for tissue repair. The key is to stimulate this process. In vitro and in vivo research suggests SynovX Tendon & Ligament does just that. This proprietary blend of type I collagen and mucopolysaccharides combined with vitamin C supports the structural and functional needs of tendons and ligaments.

Type I Collagen and Mucopolysaccharides Adult tendons are comprised mainly of type-l collagen molecules that are hierarchically organized into structural units. The molecular structure and organization of tendon and ligament collagen fibrils are key determinants in the ability of these tissues to endure mechanical force and fuel self-repair. While collagen provides much of tendon/ligament structure and strength, mucopolysaccharides are said to provide the "glue" that holds them together and allows them to stretch, flex, bend, and maintain their resilience. Mucopolysaccharides also known as glycosaminoglycans or GAGS are a critical component of ECM and are important in maintaining structural integrity, lubrication, and spacing of collagen fibers. Furthermore, mucopolysaccharides have been shown to increase collagen and non-collagenous protein synthesis in cultures of bovine tenocytes and ligament cells.

Vitamin C This vitamin helps maintain tendon/ligament structure and biomechanical properties by stimulating collagen biosynthesis.In Vitro IL-1beta (interleukin-1 beta) is a cytokine associated with adverse tendon/ligament changes. The effect of SynovX Tendon & Ligament in the presence of IL-1 beta was studied in primary human tenocytes. Tenocyte cultures treated with 250, 500, and 1000 µg/ml of SynovX Tendon & Ligament showed no signs of cytotoxicity or other negative effects on the viability of cells. The major findings were that this formula counteracted the negative effects of IL-1 beta by:  protecting tenocytes from degenerative morphological changes, cellular degeneration, and apoptosis, (2) reversing the downregulation of collagen type I and beta 1-integrin receptor expression, increasing tenomodulin production, and (4) causing a significant dose-and time-dependent increase in proliferation and viability of tenocytes. These results demonstrated that SynovX Tendon & Ligament supports tenocyte viability and proliferation and type I collagen synthesis. Furthermore, the treated cells appeared healthy; displayed an abundant and well-organized ECM; and exhibited high levels of euchromatin, indicating that the cells were very active and had a high rate of protein (i.e., collagen) biosynthesis. [In another in vitro test, human tenocytes incubated with SynovX Tendon & Ligament for 10 days showed a strong stimulatory effect on cell proliferation that exceeded the proliferation seen in cells incubated with (IGF-1) insulin- like growth factor 1 (positive control). In addition, cells remained viable and showed large amounts of endoplasmic reticulum, which is needed for synthesis of ECM.

In Vivo A prospective observational study performed by Nadal et al demonstrated the effects of SynovX Tendon & Ligament on the health of epicondyles, plantar fascia, Achilles tendons, or supraspinatus tendons. Patients were selected on the basis of clinical assessment and ultrasound results. For three months, all of the patients received 20 to 30 physical therapy sessions and the study group received two caps/d of SynovX Tendon & Ligament. Comfort, quality of life (SF-36), and physiotherapist assessments were performed before intervention began and also at 30-, 60-, and 90-day intervals during intervention. In every assessment, patients given SynovX Tendon & Ligament showed numerical or statistically significant improvements after two to three months of supplementation compared to controls. Researchers concluded that supplementing with SynovX Tendon & Ligament improved comfort level and biomechanical properties without adverse effects.

Brand: Xymogen
Isin: IAQVZSM2MSZK

$101.05

$101.84
1% off
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Xymogen SynovX T & L 60 Veggie Caps

Xymogen SynovX T & L 60 Veggie Caps

$101.05 $101.84 (1% off)

SynovX T & L

  • Made In Canada
  • Helps to relieve joint pain associated with osteoarthritis

It is known that tendons and ligaments have a slower and more limited ability to self-repair than other tissues. However, healthy tendons and ligaments do indeed have an intrinsic capacity for repair, which is controlled by resident fibroblasts and their surrounding extracellular matrix (ECM). Fibroblasts (e.g., tenocytes) are responsible for producing the ECM and therefore the proteoglycans (protein/mucopolysaccharide complex) and collagen needed for tissue repair. The key is to stimulate this process. In vitro and in vivo research suggests SynovX Tendon & Ligament does just that. This proprietary blend of type I collagen and mucopolysaccharides combined with vitamin C supports the structural and functional needs of tendons and ligaments.

Type I Collagen and Mucopolysaccharides Adult tendons are comprised mainly of type-l collagen molecules that are hierarchically organized into structural units. The molecular structure and organization of tendon and ligament collagen fibrils are key determinants in the ability of these tissues to endure mechanical force and fuel self-repair. While collagen provides much of tendon/ligament structure and strength, mucopolysaccharides are said to provide the "glue" that holds them together and allows them to stretch, flex, bend, and maintain their resilience. Mucopolysaccharides also known as glycosaminoglycans or GAGS are a critical component of ECM and are important in maintaining structural integrity, lubrication, and spacing of collagen fibers. Furthermore, mucopolysaccharides have been shown to increase collagen and non-collagenous protein synthesis in cultures of bovine tenocytes and ligament cells.

Vitamin C This vitamin helps maintain tendon/ligament structure and biomechanical properties by stimulating collagen biosynthesis.In Vitro IL-1beta (interleukin-1 beta) is a cytokine associated with adverse tendon/ligament changes. The effect of SynovX Tendon & Ligament in the presence of IL-1 beta was studied in primary human tenocytes. Tenocyte cultures treated with 250, 500, and 1000 µg/ml of SynovX Tendon & Ligament showed no signs of cytotoxicity or other negative effects on the viability of cells. The major findings were that this formula counteracted the negative effects of IL-1 beta by:  protecting tenocytes from degenerative morphological changes, cellular degeneration, and apoptosis, (2) reversing the downregulation of collagen type I and beta 1-integrin receptor expression, increasing tenomodulin production, and (4) causing a significant dose-and time-dependent increase in proliferation and viability of tenocytes. These results demonstrated that SynovX Tendon & Ligament supports tenocyte viability and proliferation and type I collagen synthesis. Furthermore, the treated cells appeared healthy; displayed an abundant and well-organized ECM; and exhibited high levels of euchromatin, indicating that the cells were very active and had a high rate of protein (i.e., collagen) biosynthesis. [In another in vitro test, human tenocytes incubated with SynovX Tendon & Ligament for 10 days showed a strong stimulatory effect on cell proliferation that exceeded the proliferation seen in cells incubated with (IGF-1) insulin- like growth factor 1 (positive control). In addition, cells remained viable and showed large amounts of endoplasmic reticulum, which is needed for synthesis of ECM.

In Vivo A prospective observational study performed by Nadal et al demonstrated the effects of SynovX Tendon & Ligament on the health of epicondyles, plantar fascia, Achilles tendons, or supraspinatus tendons. Patients were selected on the basis of clinical assessment and ultrasound results. For three months, all of the patients received 20 to 30 physical therapy sessions and the study group received two caps/d of SynovX Tendon & Ligament. Comfort, quality of life (SF-36), and physiotherapist assessments were performed before intervention began and also at 30-, 60-, and 90-day intervals during intervention. In every assessment, patients given SynovX Tendon & Ligament showed numerical or statistically significant improvements after two to three months of supplementation compared to controls. Researchers concluded that supplementing with SynovX Tendon & Ligament improved comfort level and biomechanical properties without adverse effects.

Supplement Facts

Medicinal Ingredients

(per vegetarian capsule)  
TENDOACTIVE Chondroitin sulfate (chondroitin sulfate sodium from bovine cartilage) 220 mg
TENDOACTIVE Hydrolyzed collagen (Bos taurus) 40 mg
Vitamin C (ascorbic acid) 30 mg

 

Non-Medicinal Ingredients

Hypromellose (capsule), microcrystalline cellulose, ascorbyl palmitate, silica, medium-chain triglycerides.

Suggested Use

Recommended Dose

Adults: Take two capsules twice daily, or as directed by your healthcare professional. Use for a minimum of 3 months to see beneficial effects.

Consult your healthcare practitioner prior to use if you are pregnant or breastfeeding. Consult a health- care practitioner if symptoms worsen. Some people may experience mild gastrointestinal disturbances such as diarrhoea, abdominal pain, heartburn, nausea and vomiting; in which case, discontinue use.

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Please note that these are estimates, not guarantees. Delivery time depends on a number of variables, and there may be delays such as bad weather affecting air transport, or a package being held for inspection by Customs. ibspot is not liable for any delays in international transportation or customs clearance.

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Return: 

You may return most items within 30 days of delivery for a full refund.

To be eligible for a return, your item must be unused and in the same condition that you received it. It must also be in the original packaging.

Several types of goods are exempt from being returned. Perishable goods such as food, flowers, newspapers or magazines cannot be returned. We also do not accept products that are intimate or sanitary goods, hazardous materials, or flammable liquids or gases.

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There are certain situations where only partial refunds are granted (if applicable)

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Items returned to us that were not the result of our error, including items returned to us due to an invalid or incomplete address, will be refunded the original item price less our standard restocking fees.

You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).

If you need to return an item, please Contact Us with your order number and details about the product you would like to return. We will respond quickly with instructions for how to return items from your order.


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We'll pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.). In other cases, you will be responsible for paying for your own shipping costs for returning your item. Shipping costs are non-refundable. If you receive a refund, the cost of return shipping will be deducted from your refund.

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If you are shipping an item over $75, you should consider using a trackable shipping service or purchasing shipping insurance. We don’t guarantee that we will receive your returned item.

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  • Refund will be issued to your original form of payment.
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• Returns to a IBSPOT store will be refunded to the original form of payment or gift card. • Mail-in returns with our prepaid return label will be refunded back to the original form of payment within 3-5  business days after we receive your return. Please allow 5-7 business days for your return to arrive at our Returns Center. 

• Note: It may take a few days until your bank posts the refund to your account. 

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Claims related to the product. Be sure to check the details of your purchase carefully before you make the payment, and  check the contents of the package(s) promptly upon receipt. If you have a problem with the product, visit our Support  Center to find out about return shipping arrangements. 

WHICH CIRCUMSTANCES WE OFFER RETURND & REFUND: 

WRONG PRODUCT: 

If you discover your order is flawed please contact us Mail: support@ibspot.com. With photos of the wrong product we will providing a return shipping label. Once it is tracking we will ship a replacement a product immediately. 

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Please inspect your order upon reception and contact us immediately if the item is defective,  damaged or if you receive the wrong item, so that we can evaluate the issue and make it right. 

Exceptions / non-returnable items 

Certain types of items cannot be returned, like perishable goods (such as food, flowers, or plants),  custom products (such as special orders or personalized items), and personal care goods (such as  beauty products). We also do not accept returns for hazardous materials, flammable liquids, or  gases. Please get in touch if you have questions or concerns about your specific item. Unfortunately, we cannot accept returns on sale items or gift cards. 

Exchanges 

The fastest way to ensure you get what you want is to return the item you have, and once the return  is accepted, make a separate purchase for the new item. 

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