MDS Labs Cao Dou Kou Alpinetin Liver Guard | Antioxidant Hepato-Detox Capsules
MDS Labs Cao Dou Kou Alpinetin Liver Guard | Antioxidant Hepato-Detox Capsules
MDS Labs Cao Dou Kou Alpinetin Liver Guard | Antioxidant Hepato-Detox Capsules
Cao Dou Kou
Alpinia katsumadai Extract
(6% Alpinetin)
Alpinetin Liver Guard | Antioxidant Hepato-Detox Capsules
400mg Capsules
- Includes 400mg per capsule of Cao Dou Kou Extract (Alpinia katsumadai)
- Standardized to 6% Alpinetin
- Supports Neuroprotection, Longevity, Bone Health, and Improved Metabolic Function
- Associated with decreased intestinal inflammation and oxidative stress, and demonstrates potential in treatment of Ulcerative Colitis
- Natural, Gluten Free, Vegan, Non GMO
- Includes 30 Capsules
- Free US Shipping
Nature's Herbal Rapamyc1n with Powerful Anti-Aging and Health Benefits
Alpinia katsumadai has been used for thousands of years in traditional Chinese medicine, known as Cao Dou Kou. Several compounds found in Alpinia katsumadai, specifically Alpinetin and EMC, are thought to have significant anti-aging benefits. It has been recently referred to as nature's herbal Rapamyc1n. Rapamyc1n is the only compound currently known to extend lifespan in mammals. It has shown potential against inflammation, liver disorders, cardiovascular issues, bacterial and viral infections, lung injuries, brain ailments, and oxidative stress, largely through its ability to inhibit specific signaling pathways. EMC is thought to increase cell aptosis through regulation of apoptic signaling, and MAPK / ALP pathways.
Alpinetin: A Compound with Remarkable Potential
Alpinetin’s activities are noteworthy, influencing apoptosis, cell cycle arrest, and metastasis across various problematic cell lines via pathways such as ROS/NF-κB/HIF-1α, PI3K/Akt/mTOR (Rapamyc1n target), and STAT3/c-Myc/survivin. Its anti-inflammatory effects are mediated through mechanisms including PI3K/Akt, TLR4/NF-κB, and ERK/JNK/p38 MAPK inhibition, showcasing substantial efficacy in diverse inflammatory models. Moreover, Alpinetin’s hepatoprotective, cardiovascular protective, antimicrobial, antiviral, antioxidant, and DNA/protein interaction capabilities further promote its potential as a multi-target treatment candidate.
Research has shown that Alpinetin’s anti-aging potential comes from its ability to inhibit STAT3 and ERK. The STAT3 protein transmits signals for the maturation of immune system cells, It is considered a major intrinsic pathway for malignant inflammation. It was also highlighted that Alpinetin can downregulate cyclin-D1, a pathway also inhibited by Dasatin1b. Dacatin1b and Quercetin are combined in the break-through senolytic treatment called D+Q.
A 2023 study further confirmed, through Western blot assay, Alpinia katsumadai's signal transduction ability for phosphoinosmde-3-kinase (PI3K), protein kinase B (AKT), and mTOR, target of Rapamyc1n. [1] Rapamyc1n is the only known compound that consistently demonstrates the ability to increase mammalian longevity, however, it is thought that Alpinia kastsumadai might also share these powerful longevity-enhancing properties. [2]
In 2011, it was found that Alpinia katsumadai seed extract provided significant neuroprotective qualities in a gerbil model of ischemic damage, which was further supported in a previous study on Chinese hamster lung fibroblasts. The group treated with Alpinia katsumadai had significantly increased BDNF immunoreactivity in the CA region after 12 hours post-ischemia, compared to the control group. BDNF, a neurotrophic factor, has been associated with neuronal survival, synaptic plasticity, learning and memory, in addition to neuronal plasticity. [3]
Enhancing Bone Health through regulation of apoptic signaling, mapk and alp activities
Interestingly, another study from 2020 showed that (E)-methyl-cinnamate (EMC) isolated from Alpinia Katsumadai increases cell aptosis, and decreases cell migration and osteoblast differentiation, through the regulation of apoptic signaling, and MAPKs and ALP activities in pre-osteoblasts (precurser to cells that form new bones and grow and repair existing ones). Their data suggests that EMC might be a useful phytotherapeutic compound to improve abnormalities of osteoblast function in bone disease.[4]
improving Metabolic Function by activating ppar
Alpinetin is thought to be a powerful activator of PPAR (Peroxisome proliferator-activated receptors). They are a family of nuclear receptors that regulate energy homeostasis and metabolic function. PPAR activators can:
- Improve cardiovascular risk factors by reducing triglycerides and VLDL particles, increasing HDL cholesterol, and inhibiting foam cell formation.
- Reduce the risk of acute myocardial infarction, stroke, or heart failure.
- Reduce insulin resistance and blood glucose levels, and improve cognitive and functional abilities in diabetic individuals with mild Alzhe1mer's disease.
- Have anti-inflammatory effects in vascular smooth muscle cells, monocyte/macrophages, endothelial cells, and adipocytes.
- Suppress macrophage-derived inflammation. PPARα activation can improve immunity in PD-1 blockade malignancy immunotherapy by reprogramming CD8+ T-cell metabolism.
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
ABOUT MDS LABS
| Brand: | MDS Labs |
|---|---|
| Isin: | IKKOTNQZXCEK |
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Cao Dou Kou
Alpinia katsumadai Extract
(6% Alpinetin)
Alpinetin Liver Guard | Antioxidant Hepato-Detox Capsules
400mg Capsules
- Includes 400mg per capsule of Cao Dou Kou Extract (Alpinia katsumadai)
- Standardized to 6% Alpinetin
- Supports Neuroprotection, Longevity, Bone Health, and Improved Metabolic Function
- Associated with decreased intestinal inflammation and oxidative stress, and demonstrates potential in treatment of Ulcerative Colitis
- Natural, Gluten Free, Vegan, Non GMO
- Includes 30 Capsules
- Free US Shipping
Nature's Herbal Rapamyc1n with Powerful Anti-Aging and Health Benefits
Alpinia katsumadai has been used for thousands of years in traditional Chinese medicine, known as Cao Dou Kou. Several compounds found in Alpinia katsumadai, specifically Alpinetin and EMC, are thought to have significant anti-aging benefits. It has been recently referred to as nature's herbal Rapamyc1n. Rapamyc1n is the only compound currently known to extend lifespan in mammals. It has shown potential against inflammation, liver disorders, cardiovascular issues, bacterial and viral infections, lung injuries, brain ailments, and oxidative stress, largely through its ability to inhibit specific signaling pathways. EMC is thought to increase cell aptosis through regulation of apoptic signaling, and MAPK / ALP pathways.
Alpinetin: A Compound with Remarkable Potential
Alpinetin’s activities are noteworthy, influencing apoptosis, cell cycle arrest, and metastasis across various problematic cell lines via pathways such as ROS/NF-κB/HIF-1α, PI3K/Akt/mTOR (Rapamyc1n target), and STAT3/c-Myc/survivin. Its anti-inflammatory effects are mediated through mechanisms including PI3K/Akt, TLR4/NF-κB, and ERK/JNK/p38 MAPK inhibition, showcasing substantial efficacy in diverse inflammatory models. Moreover, Alpinetin’s hepatoprotective, cardiovascular protective, antimicrobial, antiviral, antioxidant, and DNA/protein interaction capabilities further promote its potential as a multi-target treatment candidate.
Research has shown that Alpinetin’s anti-aging potential comes from its ability to inhibit STAT3 and ERK. The STAT3 protein transmits signals for the maturation of immune system cells, It is considered a major intrinsic pathway for malignant inflammation. It was also highlighted that Alpinetin can downregulate cyclin-D1, a pathway also inhibited by Dasatin1b. Dacatin1b and Quercetin are combined in the break-through senolytic treatment called D+Q.
A 2023 study further confirmed, through Western blot assay, Alpinia katsumadai's signal transduction ability for phosphoinosmde-3-kinase (PI3K), protein kinase B (AKT), and mTOR, target of Rapamyc1n. [1] Rapamyc1n is the only known compound that consistently demonstrates the ability to increase mammalian longevity, however, it is thought that Alpinia kastsumadai might also share these powerful longevity-enhancing properties. [2]
In 2011, it was found that Alpinia katsumadai seed extract provided significant neuroprotective qualities in a gerbil model of ischemic damage, which was further supported in a previous study on Chinese hamster lung fibroblasts. The group treated with Alpinia katsumadai had significantly increased BDNF immunoreactivity in the CA region after 12 hours post-ischemia, compared to the control group. BDNF, a neurotrophic factor, has been associated with neuronal survival, synaptic plasticity, learning and memory, in addition to neuronal plasticity. [3]
Enhancing Bone Health through regulation of apoptic signaling, mapk and alp activities
Interestingly, another study from 2020 showed that (E)-methyl-cinnamate (EMC) isolated from Alpinia Katsumadai increases cell aptosis, and decreases cell migration and osteoblast differentiation, through the regulation of apoptic signaling, and MAPKs and ALP activities in pre-osteoblasts (precurser to cells that form new bones and grow and repair existing ones). Their data suggests that EMC might be a useful phytotherapeutic compound to improve abnormalities of osteoblast function in bone disease.[4]
improving Metabolic Function by activating ppar
Alpinetin is thought to be a powerful activator of PPAR (Peroxisome proliferator-activated receptors). They are a family of nuclear receptors that regulate energy homeostasis and metabolic function. PPAR activators can:
- Improve cardiovascular risk factors by reducing triglycerides and VLDL particles, increasing HDL cholesterol, and inhibiting foam cell formation.
- Reduce the risk of acute myocardial infarction, stroke, or heart failure.
- Reduce insulin resistance and blood glucose levels, and improve cognitive and functional abilities in diabetic individuals with mild Alzhe1mer's disease.
- Have anti-inflammatory effects in vascular smooth muscle cells, monocyte/macrophages, endothelial cells, and adipocytes.
- Suppress macrophage-derived inflammation. PPARα activation can improve immunity in PD-1 blockade malignancy immunotherapy by reprogramming CD8+ T-cell metabolism.
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
ABOUT MDS LABS
- Main Purpose: Anti-Aging, General Wellness
- Expiration Date: Approximately 2 Years
- Servings Per Bottle: 30
- Ingredients: Alpinia, capsule (gelatin)
- Product: Cao Cou Kou
- MPN: ALP-10-30
- Dosage: 400mg
- Modified Item: No
- Brand: MDS Labs
- Active Ingredients: alpinia katsumadai
- Department: Unisex
- Type: Supplement
- Number of Capsules: 30
- Formulation: Capsule
- Milligrams Per Serving: 400mg
- Number of Pills: 30
- Features: Gluten Free, Gluten-Free, Non-GMO
- Serving Size: 1 Capsule
- Item Weight: 3.6 oz
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| Shipping Method | Estimated Delivery | Cost |
|---|---|---|
| Free Shipping (US) | 5–10 business days | Free, available on eligible items |
| Standard Shipping (US to US by Item) | 5–10 business days | $6.50 for the first item, $2.00 each additional |
| Standard Shipping (From US Warehouse by Weight) | 3–7 business days | Starts at $6.50, increasing by $2 for every additional 4 oz (0.25 lb) up to 1 lb, then by $4 for each additional pound beyond 1 lb. |
| Extended Delivery (Ships from Overseas Warehouse) | 10–20 business days | $14.50 for the first item, $2.00 each additional |
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