AOR Ortho-Sleep - 120 Caps
AOR Ortho-Sleep - 120 Caps
AOR Ortho-Sleep - 120 Caps
Sleep - Essential but Neglected
Rest is just as important as work. No one can achieve their full potential at work or school if the resources upon which that potential relies cannot replenish themselves. Even the benefits of a healthy diet and exercise are severely compromised (and the latter can even become detrimental) without the re-charging of the biological batteries that only quality sleep can provide. However, insomnia - as a symptom of modern stress - plagues about one in seven people at any given time, and most people will endure at least a temporary bout of some type of sleep disorder at least once in their lifetime. In addition to impaired cognitive and physical performance, insomnia can also lead to depression, increased accident risk and even heart disease.
Sleep is regulated by the body's internal clock, which keeps track of light levels, the time of day and other important cues for sleep and awakening. There are two primary types of sleep; REM (Rapid Eye Movement) sleep, which is dreaming sleep, and Non-REM sleep, which consists of four stages of progressively deeper sleep, all of which precede REM sleep. While all sleep stages are important, stages III and IV of deep sleep and REM sleep are especially vital.
Many people have trouble sleeping or have disrupted sleep patterns. People suffering from insomnia spend less time in deeper levels of sleep, wake up more often, and experience a reduction in REM sleep. In addition to stress, insomnia can be caused by a variety of other factors, including anxiety, poor diet, or a disruption of the body's internal clock - such as jet lag, all-night study sessions, or changing work hours.
Neurotransmitters
Neurotransmitters are the key to sleep regulation. These chemicals are like tiny messengers in the brain, transmitting signals from one neuron to another and modulating a huge number of functions in the human body, including sleep. Gamma-aminobutyric acid (or Gaba) is the most important inhibitory neurotransmitter in the brain. GABA acts like a "brake" during times of stress or anxiety, regulating brain excitability and inducing relaxation. GABA receptors are highly concentrated in the thymus; the region of the brain associated with sleep. GABA is effective against insomnia, and has been shown to affect the brain directly, increasing -brain waves (those associated with relaxation) and reducing -brain waves (those associated with anxiety and stress). In a small, unpublished study, GABA supplementation reduced sleep latency (transition time from wakefulness to stage I of Non-REM sleep) by 20%, and increased the time spent in late-stage deep sleep by another 20%.
Serotonin and melatonin are also key neurotransmitters. Melatonin is produced by the pineal gland in the brain, and it controls the body's internal clock. Melatonin has been shown to increase sleep time and reduce the time it takes to fall asleep. It can also help to reset the body's sleep-wake cycle, a benefit to those suffering from jet lag or a similar disruption. Supplemental melatonin's effects on sleep are extensive and well documented. One study with delayed sleep-phase insomniacs reduced sleep latency times by an average of 115 minutes. Supplemental melatonin is particularly well-researched with respect to dealing with disruptions in the body's internal clock, such as jet lag and shift work, with no fewer than 10 clinical studies demonstrating it's ability to resynchronize the body's altered circadian rhythms governing sleep.
Serotonin is essential for sleep modulation in its own right, and can also be converted by the body into melatonin. 5-HTP is (L)5-hyrdoxytryptophan, a metabolite of the amino acid tryptophan and a precursor to serotonin and melatonin. 5-HTP boosts serotonin levels, and can also increase REM and deep sleep phases, making sleep more restful. Supplemental 5-HTP has been successfully studied for the treatment of a number of conditions, including mood balance, chronic fatigue, and migraines. Studies examining its positive effects on sleep go back to the early 1970's, and a recent study revealed that 5-HTP supplementation was able to reduce the number of sleep-terror episodes in children by nearly 84%.
Other Natural Sleep Aids:
L-Theanine
L-Theanine is a non-essential amino acid found in green tea, and is responsible for the attribute known as 'relaxed alertness' that is associated with this famous eastern beverage. It can act directly on the brain, influencing brain wave patterns in a similar fashion to GABA, and also indirectly by stimulating GABA production. Supplemental L-theanine is also known to reduce anxiety by increasing -brain waves, which the brain produces in significant quantities only in states of effortless and relaxed alertness. This is precisely the kind of state that precedes stage I sleep.
Valerian
Valerian root (from the genus Valeriana with sub-species located worldwide) has been used for millennia in the traditional folk remedies of a wide range of cultures (from ancient China to ancient Greece) to promote calmness, relaxation and sleep. Valerian root contains essential oils which provide most of its sedative effect, while fractions known as valepotriates add a regulatory inhibiting effect on the central nervous system. There are about 150 other constituents of GABA, a great many of which act synergistically to account for Valerian's overall efficacy, which includes the stimulation of GABA. There are several placebo-controlled human studies attesting to Valerian's effectiveness against insomnia, particularly via the reduction of sleep latency and the improvement in sleep quality. These studies were also fairly large and spanned a wide range of age groups from both genders, with one study conducted among 128 test subjects where the greatest benefit was for self-described "poor sleepers".
Passionflower
Passionflower, or Passiflora incarnate L., is officially listed as a sleep aid in the monographs of the European Medicines Agency (an EU organization) as well as the National Heath Products Directorate (a division within Health Canada). Curiously, this is in spite of the fact that clinical studies with this product pertain mainly to anxiety and only in combination with other substances. Its ability to achieve such prominent recognition in spite of this is testament to the strength of passionflower's reputation in traditional medicine and preventative health circles. In one non-randomized clinical trial, 20 patients with psychosomatic disorders were administered with either a passionflower/valerian root combination or the neuroleptic drug Propaphenin. While the latter required six weeks to reduce cranial hyperactivity (using EEG brain mapping), the passionflower/valerian root extract combination did so in two. This led the scientists to conclude that "the combination product containing P. incarnata was more efficient than Propaphenin" and "has a remarkable position as an 'herbal sedative' in the OTC market." These observations can easily be carried over to have a clear effect on reducing sleep latency and to a lesser extent on improving sleep quality.
Lemon Balm
Melissa officinalis L, commonly known as lemon balm, is classified as a sleep aid in the monographs of the British, European (EU) and German Commission E Pharmacopeias as well as in the compendium of the Natural Health Products Directorate of Health Canada. With roots originating in the folk medicine traditions of southern Europe, lemon balm - like passionflower - has demonstrated its greatest efficacy when used with other herbal extracts. At least half a dozen human studies, mainly in combination with valerian root, have examined lemon balm's effects on various sleep disorders - with consistently positive results. In one multicentre, double-blind, placebo-controlled study among 98 healthy volunteers with minor sleep disorders, 33.3% of the study group reported an improvement in sleep quality vs. 9.4% of the placebo group. In another multicentre trial (this one being open), 225 patients with difficulties falling asleep, staying asleep, and experiencing states of nervous agitation participated. After taking the lemon balm-containing combination for 2 weeks, 89% saw improvements in falling asleep, 80% saw improvements in staying asleep, and 82% experienced ameliorations in nervous agitation.
Cautions:
Rest is just as important as work. No one can achieve their full potential at work or school if the resources upon which that potential relies cannot replenish themselves. Even the benefits of a healthy diet and exercise are severely compromised (and the latter can even become detrimental) without the re-charging of the biological batteries that only quality sleep can provide. However, insomnia - as a symptom of modern stress - plagues about one in seven people at any given time, and most people will endure at least a temporary bout of some type of sleep disorder at least once in their lifetime. In addition to impaired cognitive and physical performance, insomnia can also lead to depression, increased accident risk and even heart disease.
Sleep is regulated by the body's internal clock, which keeps track of light levels, the time of day and other important cues for sleep and awakening. There are two primary types of sleep; REM (Rapid Eye Movement) sleep, which is dreaming sleep, and Non-REM sleep, which consists of four stages of progressively deeper sleep, all of which precede REM sleep. While all sleep stages are important, stages III and IV of deep sleep and REM sleep are especially vital.
Many people have trouble sleeping or have disrupted sleep patterns. People suffering from insomnia spend less time in deeper levels of sleep, wake up more often, and experience a reduction in REM sleep. In addition to stress, insomnia can be caused by a variety of other factors, including anxiety, poor diet, or a disruption of the body's internal clock - such as jet lag, all-night study sessions, or changing work hours.
Neurotransmitters
Neurotransmitters are the key to sleep regulation. These chemicals are like tiny messengers in the brain, transmitting signals from one neuron to another and modulating a huge number of functions in the human body, including sleep. Gamma-aminobutyric acid (or Gaba) is the most important inhibitory neurotransmitter in the brain. GABA acts like a "brake" during times of stress or anxiety, regulating brain excitability and inducing relaxation. GABA receptors are highly concentrated in the thymus; the region of the brain associated with sleep. GABA is effective against insomnia, and has been shown to affect the brain directly, increasing -brain waves (those associated with relaxation) and reducing -brain waves (those associated with anxiety and stress). In a small, unpublished study, GABA supplementation reduced sleep latency (transition time from wakefulness to stage I of Non-REM sleep) by 20%, and increased the time spent in late-stage deep sleep by another 20%.
Serotonin and melatonin are also key neurotransmitters. Melatonin is produced by the pineal gland in the brain, and it controls the body's internal clock. Melatonin has been shown to increase sleep time and reduce the time it takes to fall asleep. It can also help to reset the body's sleep-wake cycle, a benefit to those suffering from jet lag or a similar disruption. Supplemental melatonin's effects on sleep are extensive and well documented. One study with delayed sleep-phase insomniacs reduced sleep latency times by an average of 115 minutes. Supplemental melatonin is particularly well-researched with respect to dealing with disruptions in the body's internal clock, such as jet lag and shift work, with no fewer than 10 clinical studies demonstrating it's ability to resynchronize the body's altered circadian rhythms governing sleep.
Serotonin is essential for sleep modulation in its own right, and can also be converted by the body into melatonin. 5-HTP is (L)5-hyrdoxytryptophan, a metabolite of the amino acid tryptophan and a precursor to serotonin and melatonin. 5-HTP boosts serotonin levels, and can also increase REM and deep sleep phases, making sleep more restful. Supplemental 5-HTP has been successfully studied for the treatment of a number of conditions, including mood balance, chronic fatigue, and migraines. Studies examining its positive effects on sleep go back to the early 1970's, and a recent study revealed that 5-HTP supplementation was able to reduce the number of sleep-terror episodes in children by nearly 84%.
Other Natural Sleep Aids:
L-Theanine
L-Theanine is a non-essential amino acid found in green tea, and is responsible for the attribute known as 'relaxed alertness' that is associated with this famous eastern beverage. It can act directly on the brain, influencing brain wave patterns in a similar fashion to GABA, and also indirectly by stimulating GABA production. Supplemental L-theanine is also known to reduce anxiety by increasing -brain waves, which the brain produces in significant quantities only in states of effortless and relaxed alertness. This is precisely the kind of state that precedes stage I sleep.
Valerian
Valerian root (from the genus Valeriana with sub-species located worldwide) has been used for millennia in the traditional folk remedies of a wide range of cultures (from ancient China to ancient Greece) to promote calmness, relaxation and sleep. Valerian root contains essential oils which provide most of its sedative effect, while fractions known as valepotriates add a regulatory inhibiting effect on the central nervous system. There are about 150 other constituents of GABA, a great many of which act synergistically to account for Valerian's overall efficacy, which includes the stimulation of GABA. There are several placebo-controlled human studies attesting to Valerian's effectiveness against insomnia, particularly via the reduction of sleep latency and the improvement in sleep quality. These studies were also fairly large and spanned a wide range of age groups from both genders, with one study conducted among 128 test subjects where the greatest benefit was for self-described "poor sleepers".
Passionflower
Passionflower, or Passiflora incarnate L., is officially listed as a sleep aid in the monographs of the European Medicines Agency (an EU organization) as well as the National Heath Products Directorate (a division within Health Canada). Curiously, this is in spite of the fact that clinical studies with this product pertain mainly to anxiety and only in combination with other substances. Its ability to achieve such prominent recognition in spite of this is testament to the strength of passionflower's reputation in traditional medicine and preventative health circles. In one non-randomized clinical trial, 20 patients with psychosomatic disorders were administered with either a passionflower/valerian root combination or the neuroleptic drug Propaphenin. While the latter required six weeks to reduce cranial hyperactivity (using EEG brain mapping), the passionflower/valerian root extract combination did so in two. This led the scientists to conclude that "the combination product containing P. incarnata was more efficient than Propaphenin" and "has a remarkable position as an 'herbal sedative' in the OTC market." These observations can easily be carried over to have a clear effect on reducing sleep latency and to a lesser extent on improving sleep quality.
Lemon Balm
Melissa officinalis L, commonly known as lemon balm, is classified as a sleep aid in the monographs of the British, European (EU) and German Commission E Pharmacopeias as well as in the compendium of the Natural Health Products Directorate of Health Canada. With roots originating in the folk medicine traditions of southern Europe, lemon balm - like passionflower - has demonstrated its greatest efficacy when used with other herbal extracts. At least half a dozen human studies, mainly in combination with valerian root, have examined lemon balm's effects on various sleep disorders - with consistently positive results. In one multicentre, double-blind, placebo-controlled study among 98 healthy volunteers with minor sleep disorders, 33.3% of the study group reported an improvement in sleep quality vs. 9.4% of the placebo group. In another multicentre trial (this one being open), 225 patients with difficulties falling asleep, staying asleep, and experiencing states of nervous agitation participated. After taking the lemon balm-containing combination for 2 weeks, 89% saw improvements in falling asleep, 80% saw improvements in staying asleep, and 82% experienced ameliorations in nervous agitation.
Cautions:
Do not take Ortho Sleep™ if pregnant, breastfeeding, trying to conceive, or taking immunosuppressive drugs. Not to be used by individuals under the age of 18 or those with a medical condition. Do not use if you have scleroderma.
Consult a health care practitioner prior to use if taking sedatives, hypnotic medication, psychotropic medications, blood pressure medication, anticoagulant, anticonvulsant, steroids, carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea, anti-blood pressure and anti-migraine medication. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Mild gastrointestinal symptoms (e.g. nausea, vomiting, or cramping) and hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use. Some people may experience drowsiness. Do not drive or use machinery for five hours after taking Ortho Sleep™. Exercise caution if engaging in activities requiring mental alertness. Consult a health care practitioner prior to use if you have asthma, cardiovascular disease, immune system disease, hormonal disorder, diabetes or hypoglycaemia, liver or chronic kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension, if sleeplessness persists continuously for more than three weeks (chronic insomnia or if symptoms persist or worsen. Consumption with alcohol, other medications or health products with sedative properties is not recommended.
Ortho-SleepTM was specifically formulated to be the most comprehensively powerful natural sleep aid available. It's potency is designed to effectively address short-term sleep disorders due to anxiety, stress, and/or a disruption of the body's internal clock due to such factors as shift work and/or jetlag. Due to it's unprecedented potency,Ortho-SleepTM must only be used as directed.
| Brand: | AOR |
| Isin: | IABKEOHZGSNL |
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Sleep - Essential but Neglected
Rest is just as important as work. No one can achieve their full potential at work or school if the resources upon which that potential relies cannot replenish themselves. Even the benefits of a healthy diet and exercise are severely compromised (and the latter can even become detrimental) without the re-charging of the biological batteries that only quality sleep can provide. However, insomnia - as a symptom of modern stress - plagues about one in seven people at any given time, and most people will endure at least a temporary bout of some type of sleep disorder at least once in their lifetime. In addition to impaired cognitive and physical performance, insomnia can also lead to depression, increased accident risk and even heart disease.
Sleep is regulated by the body's internal clock, which keeps track of light levels, the time of day and other important cues for sleep and awakening. There are two primary types of sleep; REM (Rapid Eye Movement) sleep, which is dreaming sleep, and Non-REM sleep, which consists of four stages of progressively deeper sleep, all of which precede REM sleep. While all sleep stages are important, stages III and IV of deep sleep and REM sleep are especially vital.
Many people have trouble sleeping or have disrupted sleep patterns. People suffering from insomnia spend less time in deeper levels of sleep, wake up more often, and experience a reduction in REM sleep. In addition to stress, insomnia can be caused by a variety of other factors, including anxiety, poor diet, or a disruption of the body's internal clock - such as jet lag, all-night study sessions, or changing work hours.
Neurotransmitters
Neurotransmitters are the key to sleep regulation. These chemicals are like tiny messengers in the brain, transmitting signals from one neuron to another and modulating a huge number of functions in the human body, including sleep. Gamma-aminobutyric acid (or Gaba) is the most important inhibitory neurotransmitter in the brain. GABA acts like a "brake" during times of stress or anxiety, regulating brain excitability and inducing relaxation. GABA receptors are highly concentrated in the thymus; the region of the brain associated with sleep. GABA is effective against insomnia, and has been shown to affect the brain directly, increasing -brain waves (those associated with relaxation) and reducing -brain waves (those associated with anxiety and stress). In a small, unpublished study, GABA supplementation reduced sleep latency (transition time from wakefulness to stage I of Non-REM sleep) by 20%, and increased the time spent in late-stage deep sleep by another 20%.
Serotonin and melatonin are also key neurotransmitters. Melatonin is produced by the pineal gland in the brain, and it controls the body's internal clock. Melatonin has been shown to increase sleep time and reduce the time it takes to fall asleep. It can also help to reset the body's sleep-wake cycle, a benefit to those suffering from jet lag or a similar disruption. Supplemental melatonin's effects on sleep are extensive and well documented. One study with delayed sleep-phase insomniacs reduced sleep latency times by an average of 115 minutes. Supplemental melatonin is particularly well-researched with respect to dealing with disruptions in the body's internal clock, such as jet lag and shift work, with no fewer than 10 clinical studies demonstrating it's ability to resynchronize the body's altered circadian rhythms governing sleep.
Serotonin is essential for sleep modulation in its own right, and can also be converted by the body into melatonin. 5-HTP is (L)5-hyrdoxytryptophan, a metabolite of the amino acid tryptophan and a precursor to serotonin and melatonin. 5-HTP boosts serotonin levels, and can also increase REM and deep sleep phases, making sleep more restful. Supplemental 5-HTP has been successfully studied for the treatment of a number of conditions, including mood balance, chronic fatigue, and migraines. Studies examining its positive effects on sleep go back to the early 1970's, and a recent study revealed that 5-HTP supplementation was able to reduce the number of sleep-terror episodes in children by nearly 84%.
Other Natural Sleep Aids:
L-Theanine
L-Theanine is a non-essential amino acid found in green tea, and is responsible for the attribute known as 'relaxed alertness' that is associated with this famous eastern beverage. It can act directly on the brain, influencing brain wave patterns in a similar fashion to GABA, and also indirectly by stimulating GABA production. Supplemental L-theanine is also known to reduce anxiety by increasing -brain waves, which the brain produces in significant quantities only in states of effortless and relaxed alertness. This is precisely the kind of state that precedes stage I sleep.
Valerian
Valerian root (from the genus Valeriana with sub-species located worldwide) has been used for millennia in the traditional folk remedies of a wide range of cultures (from ancient China to ancient Greece) to promote calmness, relaxation and sleep. Valerian root contains essential oils which provide most of its sedative effect, while fractions known as valepotriates add a regulatory inhibiting effect on the central nervous system. There are about 150 other constituents of GABA, a great many of which act synergistically to account for Valerian's overall efficacy, which includes the stimulation of GABA. There are several placebo-controlled human studies attesting to Valerian's effectiveness against insomnia, particularly via the reduction of sleep latency and the improvement in sleep quality. These studies were also fairly large and spanned a wide range of age groups from both genders, with one study conducted among 128 test subjects where the greatest benefit was for self-described "poor sleepers".
Passionflower
Passionflower, or Passiflora incarnate L., is officially listed as a sleep aid in the monographs of the European Medicines Agency (an EU organization) as well as the National Heath Products Directorate (a division within Health Canada). Curiously, this is in spite of the fact that clinical studies with this product pertain mainly to anxiety and only in combination with other substances. Its ability to achieve such prominent recognition in spite of this is testament to the strength of passionflower's reputation in traditional medicine and preventative health circles. In one non-randomized clinical trial, 20 patients with psychosomatic disorders were administered with either a passionflower/valerian root combination or the neuroleptic drug Propaphenin. While the latter required six weeks to reduce cranial hyperactivity (using EEG brain mapping), the passionflower/valerian root extract combination did so in two. This led the scientists to conclude that "the combination product containing P. incarnata was more efficient than Propaphenin" and "has a remarkable position as an 'herbal sedative' in the OTC market." These observations can easily be carried over to have a clear effect on reducing sleep latency and to a lesser extent on improving sleep quality.
Lemon Balm
Melissa officinalis L, commonly known as lemon balm, is classified as a sleep aid in the monographs of the British, European (EU) and German Commission E Pharmacopeias as well as in the compendium of the Natural Health Products Directorate of Health Canada. With roots originating in the folk medicine traditions of southern Europe, lemon balm - like passionflower - has demonstrated its greatest efficacy when used with other herbal extracts. At least half a dozen human studies, mainly in combination with valerian root, have examined lemon balm's effects on various sleep disorders - with consistently positive results. In one multicentre, double-blind, placebo-controlled study among 98 healthy volunteers with minor sleep disorders, 33.3% of the study group reported an improvement in sleep quality vs. 9.4% of the placebo group. In another multicentre trial (this one being open), 225 patients with difficulties falling asleep, staying asleep, and experiencing states of nervous agitation participated. After taking the lemon balm-containing combination for 2 weeks, 89% saw improvements in falling asleep, 80% saw improvements in staying asleep, and 82% experienced ameliorations in nervous agitation.
Cautions:
Rest is just as important as work. No one can achieve their full potential at work or school if the resources upon which that potential relies cannot replenish themselves. Even the benefits of a healthy diet and exercise are severely compromised (and the latter can even become detrimental) without the re-charging of the biological batteries that only quality sleep can provide. However, insomnia - as a symptom of modern stress - plagues about one in seven people at any given time, and most people will endure at least a temporary bout of some type of sleep disorder at least once in their lifetime. In addition to impaired cognitive and physical performance, insomnia can also lead to depression, increased accident risk and even heart disease.
Sleep is regulated by the body's internal clock, which keeps track of light levels, the time of day and other important cues for sleep and awakening. There are two primary types of sleep; REM (Rapid Eye Movement) sleep, which is dreaming sleep, and Non-REM sleep, which consists of four stages of progressively deeper sleep, all of which precede REM sleep. While all sleep stages are important, stages III and IV of deep sleep and REM sleep are especially vital.
Many people have trouble sleeping or have disrupted sleep patterns. People suffering from insomnia spend less time in deeper levels of sleep, wake up more often, and experience a reduction in REM sleep. In addition to stress, insomnia can be caused by a variety of other factors, including anxiety, poor diet, or a disruption of the body's internal clock - such as jet lag, all-night study sessions, or changing work hours.
Neurotransmitters
Neurotransmitters are the key to sleep regulation. These chemicals are like tiny messengers in the brain, transmitting signals from one neuron to another and modulating a huge number of functions in the human body, including sleep. Gamma-aminobutyric acid (or Gaba) is the most important inhibitory neurotransmitter in the brain. GABA acts like a "brake" during times of stress or anxiety, regulating brain excitability and inducing relaxation. GABA receptors are highly concentrated in the thymus; the region of the brain associated with sleep. GABA is effective against insomnia, and has been shown to affect the brain directly, increasing -brain waves (those associated with relaxation) and reducing -brain waves (those associated with anxiety and stress). In a small, unpublished study, GABA supplementation reduced sleep latency (transition time from wakefulness to stage I of Non-REM sleep) by 20%, and increased the time spent in late-stage deep sleep by another 20%.
Serotonin and melatonin are also key neurotransmitters. Melatonin is produced by the pineal gland in the brain, and it controls the body's internal clock. Melatonin has been shown to increase sleep time and reduce the time it takes to fall asleep. It can also help to reset the body's sleep-wake cycle, a benefit to those suffering from jet lag or a similar disruption. Supplemental melatonin's effects on sleep are extensive and well documented. One study with delayed sleep-phase insomniacs reduced sleep latency times by an average of 115 minutes. Supplemental melatonin is particularly well-researched with respect to dealing with disruptions in the body's internal clock, such as jet lag and shift work, with no fewer than 10 clinical studies demonstrating it's ability to resynchronize the body's altered circadian rhythms governing sleep.
Serotonin is essential for sleep modulation in its own right, and can also be converted by the body into melatonin. 5-HTP is (L)5-hyrdoxytryptophan, a metabolite of the amino acid tryptophan and a precursor to serotonin and melatonin. 5-HTP boosts serotonin levels, and can also increase REM and deep sleep phases, making sleep more restful. Supplemental 5-HTP has been successfully studied for the treatment of a number of conditions, including mood balance, chronic fatigue, and migraines. Studies examining its positive effects on sleep go back to the early 1970's, and a recent study revealed that 5-HTP supplementation was able to reduce the number of sleep-terror episodes in children by nearly 84%.
Other Natural Sleep Aids:
L-Theanine
L-Theanine is a non-essential amino acid found in green tea, and is responsible for the attribute known as 'relaxed alertness' that is associated with this famous eastern beverage. It can act directly on the brain, influencing brain wave patterns in a similar fashion to GABA, and also indirectly by stimulating GABA production. Supplemental L-theanine is also known to reduce anxiety by increasing -brain waves, which the brain produces in significant quantities only in states of effortless and relaxed alertness. This is precisely the kind of state that precedes stage I sleep.
Valerian
Valerian root (from the genus Valeriana with sub-species located worldwide) has been used for millennia in the traditional folk remedies of a wide range of cultures (from ancient China to ancient Greece) to promote calmness, relaxation and sleep. Valerian root contains essential oils which provide most of its sedative effect, while fractions known as valepotriates add a regulatory inhibiting effect on the central nervous system. There are about 150 other constituents of GABA, a great many of which act synergistically to account for Valerian's overall efficacy, which includes the stimulation of GABA. There are several placebo-controlled human studies attesting to Valerian's effectiveness against insomnia, particularly via the reduction of sleep latency and the improvement in sleep quality. These studies were also fairly large and spanned a wide range of age groups from both genders, with one study conducted among 128 test subjects where the greatest benefit was for self-described "poor sleepers".
Passionflower
Passionflower, or Passiflora incarnate L., is officially listed as a sleep aid in the monographs of the European Medicines Agency (an EU organization) as well as the National Heath Products Directorate (a division within Health Canada). Curiously, this is in spite of the fact that clinical studies with this product pertain mainly to anxiety and only in combination with other substances. Its ability to achieve such prominent recognition in spite of this is testament to the strength of passionflower's reputation in traditional medicine and preventative health circles. In one non-randomized clinical trial, 20 patients with psychosomatic disorders were administered with either a passionflower/valerian root combination or the neuroleptic drug Propaphenin. While the latter required six weeks to reduce cranial hyperactivity (using EEG brain mapping), the passionflower/valerian root extract combination did so in two. This led the scientists to conclude that "the combination product containing P. incarnata was more efficient than Propaphenin" and "has a remarkable position as an 'herbal sedative' in the OTC market." These observations can easily be carried over to have a clear effect on reducing sleep latency and to a lesser extent on improving sleep quality.
Lemon Balm
Melissa officinalis L, commonly known as lemon balm, is classified as a sleep aid in the monographs of the British, European (EU) and German Commission E Pharmacopeias as well as in the compendium of the Natural Health Products Directorate of Health Canada. With roots originating in the folk medicine traditions of southern Europe, lemon balm - like passionflower - has demonstrated its greatest efficacy when used with other herbal extracts. At least half a dozen human studies, mainly in combination with valerian root, have examined lemon balm's effects on various sleep disorders - with consistently positive results. In one multicentre, double-blind, placebo-controlled study among 98 healthy volunteers with minor sleep disorders, 33.3% of the study group reported an improvement in sleep quality vs. 9.4% of the placebo group. In another multicentre trial (this one being open), 225 patients with difficulties falling asleep, staying asleep, and experiencing states of nervous agitation participated. After taking the lemon balm-containing combination for 2 weeks, 89% saw improvements in falling asleep, 80% saw improvements in staying asleep, and 82% experienced ameliorations in nervous agitation.
Cautions:
Do not take Ortho Sleep™ if pregnant, breastfeeding, trying to conceive, or taking immunosuppressive drugs. Not to be used by individuals under the age of 18 or those with a medical condition. Do not use if you have scleroderma.
Consult a health care practitioner prior to use if taking sedatives, hypnotic medication, psychotropic medications, blood pressure medication, anticoagulant, anticonvulsant, steroids, carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea, anti-blood pressure and anti-migraine medication. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Mild gastrointestinal symptoms (e.g. nausea, vomiting, or cramping) and hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use. Some people may experience drowsiness. Do not drive or use machinery for five hours after taking Ortho Sleep™. Exercise caution if engaging in activities requiring mental alertness. Consult a health care practitioner prior to use if you have asthma, cardiovascular disease, immune system disease, hormonal disorder, diabetes or hypoglycaemia, liver or chronic kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension, if sleeplessness persists continuously for more than three weeks (chronic insomnia or if symptoms persist or worsen. Consumption with alcohol, other medications or health products with sedative properties is not recommended.
Ortho-SleepTM was specifically formulated to be the most comprehensively powerful natural sleep aid available. It's potency is designed to effectively address short-term sleep disorders due to anxiety, stress, and/or a disruption of the body's internal clock due to such factors as shift work and/or jetlag. Due to it's unprecedented potency,Ortho-SleepTM must only be used as directed.
Ingredients
- 100mg
- GABA (Gamma Aminobutyric Acid)
- 200mg
- L-Theanine (SuntheanineTM)
- 100mg
- L-5-Hydroxytryptophan (Griffonia Seed)
- 3mg
- Melatonin
- 150mg
- Valerian Root (0.8% Valerenic acid)
- 32mg
- Passionflower (3.5% Vitexin)
- 300mg
- CYRACOSTM (lemon balm extract)
Non-medicinal ingredients:
Maltodextrin, gum arabic, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.
Maltodextrin, gum arabic, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.
Format
Capsules
120 Caps
Dosage
Take one to two capsules before bedtime with or without food, or as directed by a qualified health care practitioner.
Important Information
Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. See Below for Cautions.
Manufacturer Info
AOR Canada is the innovative formulators of Canada’s best-selling antioxidant support, AOR Advanced B Complex and AOR Tri-B12. They are also known for their top bone health supplements, Ortho Adapt and Bone Basics. You can also SHOP AOR's Nattokinase, and trusted Curcumin Ultra, Curcumin Active and Curcumin95 inflammation support at National Nutrition.ca. AOR are leaders in natural health with innovative product development.
Shipping Summary:
- Packages are shipped from Monday to Friday.
- The usual time for processing an order is 1 to 3 business days, but may vary depending on the availability of products ordered. This period excludes delivery times, which depend on your geographic location.
- We provide tracking for every order. Tracking will be available once your product is shipped. Each individual product may be shipped from different fulfillment centers across the globe as our product research team spends the time to source quality yet affordable products.
Estimated delivery times:
- Standard Shipping: 3-7 business days
- Expedited Shipping: 2-5 business days
- International Shipping: 10 - 15 business days
Please note that these are estimates, not guarantees. Delivery time depends on a number of variables, and there may be delays such as bad weather affecting air transport, or a package being held for inspection by Customs. ibspot is not liable for any delays in international transportation or customs clearance.
Shipments can be delivered directly to most addresses, except post office boxes. However, in certain remote areas, there may be an additional delivery charge or you may need to pick up your package from the closest service location of ibspot's shipping partner.
Shipping Status:
As soon as your order ships, you'll receive a shipping confirmation email that includes your tracking number.
If you don't receive a shipping confirmation email right away, don't worry! We know the delivery date or date range provided at checkout and we'll be sure to deliver the items within that timeframe.
Order changes:
Please contact our customer support if the order needs to be canceled or modified.
Item not received:
If you've successfully placed an order and haven't received it yet while the tracking status shows it's delivered. you'd wish to contact the carrier to hunt out your Cover as once the item is Covered we have control over it (once it’s by the carrier), but if still persists kindly email us
Damaged Parcel
If your package has been delivered in a PO Box, please note that we are not responsible for any damage that may result (consequences of extreme temperatures, theft, etc.).
If you have any questions regarding shipping or want to know about the status of an order, please contact us or email to support@ibspot.com.
Please Read Our Return & Refund Policy Carefully:
Return:
You may return most items within 30 days of delivery for a full refund.
To be eligible for a return, your item must be unused and in the same condition that you received it. It must also be in the original packaging.
Several types of goods are exempt from being returned. Perishable goods such as food, flowers, newspapers or magazines cannot be returned. We also do not accept products that are intimate or sanitary goods, hazardous materials, or flammable liquids or gases.
Additional non-returnable items:
- Gift cards
- Downloadable software products
- Some health and personal care items
To complete your return, we require a tracking number, which shows the items which you already returned to us.
There are certain situations where only partial refunds are granted (if applicable)
- Book with obvious signs of use
- CD, DVD, VHS tape, software, video game, cassette tape, or vinyl record that has been opened
- Any item not in its original condition, is damaged or missing parts for reasons not due to our error
- Any item that is returned more than 30 days after delivery
Items returned to us as a result of our error will receive a full refund,some returns may be subject to a restocking fee of 7% of the total item price, please contact a customer care team member to see if your return is subject. Returns that arrived on time and were as described are subject to a restocking fee.
Items returned to us that were not the result of our error, including items returned to us due to an invalid or incomplete address, will be refunded the original item price less our standard restocking fees.
You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).
If you need to return an item, please Contact Us with your order number and details about the product you would like to return. We will respond quickly with instructions for how to return items from your order.
Shipping Cost
We'll pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.). In other cases, you will be responsible for paying for your own shipping costs for returning your item. Shipping costs are non-refundable. If you receive a refund, the cost of return shipping will be deducted from your refund.
Depending on where you live, the time it may take for your exchanged product to reach you, may vary.
If you are shipping an item over $75, you should consider using a trackable shipping service or purchasing shipping insurance. We don’t guarantee that we will receive your returned item.
Refund:
- Purchases may be returned within 30 days of the shipping date for a refund.
- Refund will be issued to your original form of payment.
- Refunds for orders purchased with IBSPOT Gift Cards and/or IBSPOT Notes will be issued as a IBSPOT Gift Card and mailed to the original billing address. Gift cards cannot be redeemed for cash unless required by law.
Refund Processing
• Returns to a IBSPOT store will be refunded to the original form of payment or gift card. • Mail-in returns with our prepaid return label will be refunded back to the original form of payment within 3-5 business days after we receive your return. Please allow 5-7 business days for your return to arrive at our Returns Center.
• Note: It may take a few days until your bank posts the refund to your account.
Claims:
Claims related to the product. Be sure to check the details of your purchase carefully before you make the payment, and check the contents of the package(s) promptly upon receipt. If you have a problem with the product, visit our Support Center to find out about return shipping arrangements.
WHICH CIRCUMSTANCES WE OFFER RETURND & REFUND:
WRONG PRODUCT:
If you discover your order is flawed please contact us Mail: support@ibspot.com. With photos of the wrong product we will providing a return shipping label. Once it is tracking we will ship a replacement a product immediately.
Damages and issues
Please inspect your order upon reception and contact us immediately if the item is defective, damaged or if you receive the wrong item, so that we can evaluate the issue and make it right.
Exceptions / non-returnable items
Certain types of items cannot be returned, like perishable goods (such as food, flowers, or plants), custom products (such as special orders or personalized items), and personal care goods (such as beauty products). We also do not accept returns for hazardous materials, flammable liquids, or gases. Please get in touch if you have questions or concerns about your specific item. Unfortunately, we cannot accept returns on sale items or gift cards.
Exchanges
The fastest way to ensure you get what you want is to return the item you have, and once the return is accepted, make a separate purchase for the new item.
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